Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation
Identifieur interne : 000968 ( Main/Exploration ); précédent : 000967; suivant : 000969Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation
Auteurs : Tommy Weiss-Sadan ; Gal Itzhak ; Farnusch Kaschani [Allemagne] ; Zhanru Yu [Royaume-Uni] ; Mohamed Mahameed ; Adi Anaki ; Yael Ben-Nun ; Emmanuelle Merquiol ; Boaz Tirosh ; Benedikt Kessler [Royaume-Uni] ; Markus Kaiser [Allemagne] ; Galia BlumSource :
- Molecular & Cellular Proteomics : MCP [ 1535-9476 ] ; 2019.
Abstract
Remodeling of cellular metabolism is a genuine feature of rapidly growing cells. Herein we report that mouse embryonic fibroblasts, lacking the Cathepsin L (Cts L) gene, proliferate faster than wild-types and display a noticeable glycolytic shift to satisfy their ever-growing metabolic needs. Mass spectrometry analyses identified LDHA as an essential metabolic junction in these cells, and downstream biochemical studies suggested that Cts L regulates LDHA expression and function. Together, these data uncover an unprecedented role for Cathepsin L in cell metabolism.
Url:
DOI: 10.1074/mcp.RA119.001392
PubMed: 31010818
PubMed Central: 6601214
Affiliations:
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code="subfield">9112001</wicri:noCountry></affiliation></author><author><name sortKey="Anaki, Adi" sort="Anaki, Adi" uniqKey="Anaki A" first="Adi" last="Anaki">Adi Anaki</name><affiliation><nlm:aff id="aff1">From the ‡Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel, 9112001;</nlm:aff><wicri:noCountry code="subfield">9112001</wicri:noCountry></affiliation></author><author><name sortKey="Ben Nun, Yael" sort="Ben Nun, Yael" uniqKey="Ben Nun Y" first="Yael" last="Ben-Nun">Yael Ben-Nun</name><affiliation><nlm:aff id="aff1">From the ‡Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel, 9112001;</nlm:aff><wicri:noCountry code="subfield">9112001</wicri:noCountry></affiliation></author><author><name sortKey="Merquiol, Emmanuelle" sort="Merquiol, Emmanuelle" uniqKey="Merquiol E" first="Emmanuelle" last="Merquiol">Emmanuelle Merquiol</name><affiliation><nlm:aff id="aff1">From 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Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Kaiser, Markus" sort="Kaiser, Markus" uniqKey="Kaiser M" first="Markus" last="Kaiser">Markus Kaiser</name><affiliation wicri:level="1"><nlm:aff id="aff2">§Department of Chemical Biology, University of Duisburg-Essen, Center for Medical Biotechnology, Faculty of Biology, Essen, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>§Department of Chemical Biology, University of Duisburg-Essen, Center for Medical Biotechnology, Faculty of Biology, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Blum, Galia" sort="Blum, Galia" uniqKey="Blum G" first="Galia" last="Blum">Galia Blum</name><affiliation><nlm:aff id="aff1">From the ‡Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel, 9112001;</nlm:aff><wicri:noCountry code="subfield">9112001</wicri:noCountry></affiliation></author></analytic><series><title level="j">Molecular & Cellular Proteomics : MCP</title><idno type="ISSN">1535-9476</idno><idno type="eISSN">1535-9484</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Remodeling of cellular metabolism is a genuine feature of rapidly growing cells. Herein we report that mouse embryonic fibroblasts, lacking the Cathepsin L (Cts L) gene, proliferate faster than wild-types and display a noticeable glycolytic shift to satisfy their ever-growing metabolic needs. Mass spectrometry analyses identified LDHA as an essential metabolic junction in these cells, and downstream biochemical studies suggested that Cts L regulates LDHA expression and function. Together, these data uncover an unprecedented role for Cathepsin L in cell metabolism.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lunt, S Y" uniqKey="Lunt S">S. Y. Lunt</name></author><author><name sortKey="Vander Heiden, M G" uniqKey="Vander Heiden M">M. G. Vander Heiden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deberardinis, R J" uniqKey="Deberardinis R">R. J. DeBerardinis</name></author><author><name sortKey="Lum, J J" uniqKey="Lum J">J. J. 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Guan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><noCountry><name sortKey="Anaki, Adi" sort="Anaki, Adi" uniqKey="Anaki A" first="Adi" last="Anaki">Adi Anaki</name><name sortKey="Ben Nun, Yael" sort="Ben Nun, Yael" uniqKey="Ben Nun Y" first="Yael" last="Ben-Nun">Yael Ben-Nun</name><name sortKey="Blum, Galia" sort="Blum, Galia" uniqKey="Blum G" first="Galia" last="Blum">Galia Blum</name><name sortKey="Itzhak, Gal" sort="Itzhak, Gal" uniqKey="Itzhak G" first="Gal" last="Itzhak">Gal Itzhak</name><name sortKey="Mahameed, Mohamed" sort="Mahameed, Mohamed" uniqKey="Mahameed M" first="Mohamed" last="Mahameed">Mohamed Mahameed</name><name sortKey="Merquiol, Emmanuelle" sort="Merquiol, Emmanuelle" uniqKey="Merquiol E" first="Emmanuelle" last="Merquiol">Emmanuelle Merquiol</name><name sortKey="Tirosh, Boaz" sort="Tirosh, Boaz" uniqKey="Tirosh B" first="Boaz" last="Tirosh">Boaz Tirosh</name><name sortKey="Weiss Sadan, Tommy" sort="Weiss Sadan, Tommy" uniqKey="Weiss Sadan T" first="Tommy" last="Weiss-Sadan">Tommy Weiss-Sadan</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Kaschani, Farnusch" sort="Kaschani, Farnusch" uniqKey="Kaschani F" first="Farnusch" last="Kaschani">Farnusch Kaschani</name></noRegion><name sortKey="Kaiser, Markus" sort="Kaiser, Markus" uniqKey="Kaiser M" first="Markus" last="Kaiser">Markus Kaiser</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Yu, Zhanru" sort="Yu, Zhanru" uniqKey="Yu Z" first="Zhanru" last="Yu">Zhanru Yu</name></region><name sortKey="Kessler, Benedikt" sort="Kessler, Benedikt" uniqKey="Kessler B" first="Benedikt" last="Kessler">Benedikt Kessler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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